帕博西利布
医学
糖尿病性心肌病
背景(考古学)
心功能曲线
纤维化
心肌病
心脏纤维化
链脲佐菌素
内科学
心力衰竭
药理学
内分泌学
糖尿病
癌症
生物
转移性乳腺癌
乳腺癌
古生物学
作者
Zhenggui Wang,Jing Li,Yonggang Wang,Quan Liu
出处
期刊:PubMed
日期:2019-01-01
卷期号:11 (6): 3481-3489
被引量:9
摘要
Diabetic cardiomyopathy (DCM) is a condition associated with significant structural changes including cardiac tissue necrosis, localized fibrosis, and hypertrophy of cardiomyocytes. This study sought to assess whether and how CDK4/6 inhibitor, Palbociclib, can attenuate DCM using a streptozotocin (STZ)-induced DCM model system. In this study, we found CDK4 and CDK6 expression are significantly increased the cardiac tissue of these mice. Palbociclib treatment after initial STZ administration attenuated oxidative stress and inflammation, thereby reducing cardiomyocyte death and preserving cardiac function in these animals. In addition, Rb phosphorylation induction was found in STZ-treated mice, which was inhibited by Palbociclib treatment. In summary, Palbociclib protects mice from damage associated with DCM pathway activation, making Palbociclib is a relevant therapeutic target in the context of DCM.
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