杨梅素
溃疡性结肠炎
药理学
结肠炎
促炎细胞因子
化学
免疫系统
免疫学
医学
炎症
内科学
生物化学
抗氧化剂
类黄酮
疾病
山奈酚
作者
Xinyan Qu,Qingjun Liu,Yue Song,Anqi Xue,Yuhua Liu,Dongmei Qi,Hao Dong
摘要
Myricetin is a bioactive compound in many edible plants with anti-inflammatory and anticarcinogenic activity. The current study aimed to determine the protective effects and mechanism of myricetin against ulcerative colitis (UC).Myricetin was orally administered at doses of 40 and 80 mg/kg to C57BL/6 mice with UC induced using dextran sulfate sodium. The disease-associated index and colon length were determined at the end of the experiment, the proportion of Treg, Th1 and Th17 was analysed by cytometry, and cytokines were detected using ELISA.Myricetin (80 mg/kg) ameliorated the severity of inflammation in acute UC and significantly improved the condition. Myricetin (80 mg/kg) elevated the levels of IL-10 and transforming growth factor β. In addition, the proportion of regulatory T cells significantly increased in mice in the myricetin treatment group.Taking together, these results suggest that myricetin exhibits significant protective effects against UC and it could be used as a potential treatment for UC.
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