烯烃
光催化
有机硅
化学
硅烷化
芳基
催化作用
试剂
烷基
反应性(心理学)
组合化学
镍
有机化学
光化学
光催化
替代医学
病理
医学
标识
DOI:10.1021/acscatal.9b04916
摘要
Carbosilylation of alkenes can be an efficient approach to the synthesis of organosilicon compounds. However, few general methods of carbosilylation are known. Here, we introduce a strategy for arylsilylation of electron-deficient terminal alkenes by combining photoredox-catalyzed silyl radical generation, innate reactivity of silyl radical with alkene, and Ni-catalyzed aryl-alkyl cross-coupling. This cooperative photoredox and nickel catalysis operates under mild conditions. It employs readily available alkenes, aryl bromides, and silane as reagents, and it produces useful synthetic building blocks in a modular manner.
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