Synthesis of 1, 4, 5, 6-Tetrahydro 2-Methyl 4-Pyrimidine Carboxylic Acid: Osmoprotector Amino Acid

Abstract Synthesis of 1, 4, 5, 6-Tetrahydro 2-methyl 4-pyrimidine carboxylic acid (Ectoine) is achieved by thermal cyclization of N-Acetyl diaminobutyric acid, itself synthesized by acetylation of (L) 2,4-diaminobutyric acid.