列线图
医学
内科学
肿瘤科
流行病学
淋巴瘤
放射治疗
监测、流行病学和最终结果
阶段(地层学)
化疗
外科
癌症登记处
生物
古生物学
作者
Soon Khai Low,Ahmad Helmy Zayan,Obaida Istanbuly,Nguyen Tran Minh Duc,Amr Ebied,Gehad Mohamed Tawfik,Nguyen Tien Huy
标识
DOI:10.1080/10428194.2019.1633636
摘要
Primary pulmonary lymphomas (PPLs) are rare lymphoproliferative malignancies arising from the lungs. The prognostic factors and optimal management of PPL have not been clearly defined due to its rarity. This study sought to characterize the significant prognostic factors and develop a validated nomogram for individualized prediction of survival outcomes in patients with PPL. A total of 2325 patients diagnosed with PPL between 1983 and 2010 were identified using the Surveillance, Epidemiology, and End Results (SEER) database. Older age at diagnosis, males, Hispanic race, non-marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue histology, Ann Arbor stage IV were significantly associated with worse OS on multivariable analysis. All treatment modalities, including chemotherapy, surgery, and radiotherapy were independent predictors of survival on univariable analysis. The nomogram built demonstrated good discriminative ability and calibration, with the C-index of 0.690 and 0.730 in the training and validation cohorts, respectively.
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