Nanoparticles from Cuttlefish Ink Inhibit Tumor Growth by Synergizing Immunotherapy and Photothermal Therapy

光热治疗 免疫疗法 免疫系统 癌症研究 材料科学 体内 癌症免疫疗法 细胞毒性T细胞 生物相容性 生物 体外 纳米技术 免疫学 生物化学 生物技术 冶金
作者
Rong‐Hui Deng,Mei‐Zhen Zou,Di‐Wei Zheng,Song Peng,Wenlong Liu,Xue‐Feng Bai,Han-Shi Chen,Yunxia Sun,Panghu Zhou,Xian‐Zheng Zhang
出处
期刊:ACS Nano [American Chemical Society]
卷期号:13 (8): 8618-8629 被引量:132
标识
DOI:10.1021/acsnano.9b02993
摘要

Natural nanoparticles have been extensively studied due to their diverse properties and easy accessibility. Here, the nanoparticles extracted from cuttlefish ink (CINPs) with significant antitumor efficacy are explored. These CINPs, with spherical morphology, good dispersibility, and biocompatibility, are rich in melanin and contain a variety of amino acids and monosaccharides. Through the activation of mitogen-activated protein kinase (MAPK) signaling pathway, CINPs can efficiently reprogram tumor-associated macrophages (TAMs) from immune-suppressive M2-like phenotype to antitumor M1-like phenotype. Besides, under near-infrared (NIR) irradiation, CINPs exhibit high photothermal effect and tumor cell killing ability, which make them a potential candidate in photothermal therapy (PTT) of tumor. In vivo, CINPs can increase the proportion of M1 macrophages and foster the recruitment of cytotoxic T lymphocytes (CTLs) to tumors, leading to reduced primary tumor growth and lung metastasis. In combination with their photothermal effect, which can induce tumor-specific antigens release, CINPs could almost completely inhibit tumor growth accompanied by more active immune responses. Collectively, these CINPs described here can provide both tumor immunotherapy and PTT, implying that CINPs are promising for tumor treatment.
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