接收机工作特性
中央后回
医学
静息状态功能磁共振成像
额上回
神经心理学
内科学
脑回
心脏病学
精神科
功能磁共振成像
认知
放射科
作者
Xiaolou Li,Peng Zhāng,Wensu Zhou,Yuan Li,Zhongru Sun,Jinhua Chen,Jianguo Xia,Hongmei Zou
出处
期刊:Journal of Investigative Medicine
[BMJ]
日期:2022-12-01
卷期号:70 (8): 1746-1752
被引量:1
标识
DOI:10.1136/jim-2021-001941
摘要
This study used a voxel-wise degree centrality (DC) method to evaluate differences in brain activity between patients with non-neuropsychiatric systemic lupus erythematosus (non-NP-SLE) and healthy controls (HCs) and to assess the relationship of DC values with clinical and neuropsychological data. Thirty-two female patients with non-NP-SLE and 28 well-matched HCs were recruited and underwent resting-state functional MRI. Differences in spontaneous brain activity between the two groups were evaluated using a DC method. Correlations between the altered DC values of specific brain regions and clinical and neuropsychological data were explored using Spearman correlation analysis. Receiver operating characteristics curve analysis was applied to differences in DC values in specific brain regions to determine their value in distinguishing patients with non-NP-SLE from HCs. Compared with HCs, DC values in patients with non-NP-SLE were significantly lower in the bilateral postcentral gyrus and the orbital part of the left superior frontal gyrus (LFMO). DC values in some specific brain regions such as the bilateral postcentral gyrus and the LFMO correlated with Mini-Mental State Examination scores in both subject groups. In patients with non-NP-SLE, DC values of the right postcentral gyrus were positively correlated with IgA levels, and DC values of the LFMO were positively correlated with Systemic Lupus Erythematosus Disease Activity Index 2000 scores, as well as IgA levels. Receiver operating characteristics curve analysis revealed that the DC values of specific brain regions can be used to differentiate patients with non-NP-SLE from HCs.
科研通智能强力驱动
Strongly Powered by AbleSci AI