Hepatitis C virus infection and risk of gallstones: A meta-analysis

Journal of Evidence-Based MedicineVolume 10, Issue 4 p. 263-270 ARTICLE Hepatitis C virus infection and risk of gallstones: A meta-analysis Karn Wijarnpreecha, Corresponding Author Karn Wijarnpreecha dr.karn.wi@gmail.com Department of Internal Medicine, Bassett Medical Center, Cooperstown, NY, USA Correspondence Karn Wijarnpreecha, Department of Internal Medicine, Bassett Medical Center, One Atwell Road, Cooperstown, NY 13326, USA. Email: dr.karn.wi@gmail.comSearch for more papers by this authorCharat Thongprayoon, Charat Thongprayoon Department of Internal Medicine, Bassett Medical Center, Cooperstown, NY, USASearch for more papers by this authorPanadeekarn Panjawatanan, Panadeekarn Panjawatanan Department of Biochemistry, Faculty of Medicine, Chiang Mai University, Chiang Mai, ThailandSearch for more papers by this authorNatasorn Lekuthai, Natasorn Lekuthai Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, ThailandSearch for more papers by this authorPatompong Ungprasert, Patompong Ungprasert Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand Division of Rheumatology, Department of Medicine, Mayo Clinic, Rochester, Minnesota, USASearch for more papers by this author Karn Wijarnpreecha, Corresponding Author Karn Wijarnpreecha dr.karn.wi@gmail.com Department of Internal Medicine, Bassett Medical Center, Cooperstown, NY, USA Correspondence Karn Wijarnpreecha, Department of Internal Medicine, Bassett Medical Center, One Atwell Road, Cooperstown, NY 13326, USA. Email: dr.karn.wi@gmail.comSearch for more papers by this authorCharat Thongprayoon, Charat Thongprayoon Department of Internal Medicine, Bassett Medical Center, Cooperstown, NY, USASearch for more papers by this authorPanadeekarn Panjawatanan, Panadeekarn Panjawatanan Department of Biochemistry, Faculty of Medicine, Chiang Mai University, Chiang Mai, ThailandSearch for more papers by this authorNatasorn Lekuthai, Natasorn Lekuthai Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, ThailandSearch for more papers by this authorPatompong Ungprasert, Patompong Ungprasert Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand Division of Rheumatology, Department of Medicine, Mayo Clinic, Rochester, Minnesota, USASearch for more papers by this author First published: 29 November 2017 https://doi.org/10.1111/jebm.12277Citations: 4 Funding: : None Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat Abstract Background/Objectives Gallstones and its complications are one of the most common hepatobiliary tract diseases. Several epidemiologic studies have suggested that patients with hepatitis C virus (HCV) infection might be at an increased risk of gallstones. However, the data on this relationship remain inconclusive. This meta-analysis was conducted with the aims to summarize all available evidence. Methods A literature search was performed using MEDLINE and EMBASE databases from inception to May 2016. Studies that reported relative risks, odd ratios, or hazard ratios comparing the risk of gallstones among HCV-infected patients versus subjects without HCV infection were included. Pooled odds ratio (OR) and 95% confidence interval (CI) were calculated using a random-effect, generic inverse variance method. Results Eleven studies met our eligibility criteria and were included in the analysis. The pooled OR of gallstones in HCV-infected patients versus subjects without HCV infection was 1.83 (95% CI, 1.35 to 2.48, I2 = 89%). Subgroup analysis showed that significant risk was increased for both male (pooled OR of 2.07, 95% CI, 1.14 to 3.76) and female (pooled OR of 3.00, 95% CI, 2.16 to 4.17). Conclusions Our study demonstrated a significantly increased risk of gallstones among HCV-infected patients. Further studies are required to clarify how this risk should be addressed in the clinical picture. Citing Literature Supporting Information Filename Description jebm12277-sup-0001-SuppMat.doc25.5 KB Online Supplementary Data jebm12277-sup-0002-SuppMat.doc63 KB Supporting Information Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article. Volume10, Issue4November 2017Pages 263-270 RelatedInformation