子宫内膜异位症
医学
病因学
内分泌系统
发病机制
疾病
不育
盆腔疼痛
免疫系统
生物信息学
激素
免疫学
内科学
怀孕
外科
生物
遗传学
作者
Bansari Patel,Emily E. Lenk,Dan I. Lebovic,Yimin Shu,Jie Yu,Robert W. Taylor
标识
DOI:10.1016/j.bpobgyn.2018.01.006
摘要
Despite an estimated prevalence of 11% in women and plausible historical descriptions dating back to the 17th century, the etiology of endometriosis remains poorly understood. Classical theories of the histological origins of endometriosis are reviewed below. Clinical presentations are variable, and signs and symptoms do not correlate well with the extent of disease. In this summary, we have attempted to synthesize the growing evidence that hormonal and immune factors conspire to activate a local inflammatory microenvironment that encourages endometriosis to persist and elaborate mediators of its two cardinal symptoms: pain and infertility. Surprisingly, in the search for novel therapeutics for medical treatment of endometriosis, some compounds appear to have dual pharmacological functions, simultaneously modifying the endocrine and immune system facets of this complex gynecologic syndrome. We predict that these lead drugs will provide more therapeutic choices for patients in the future.
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