对映选择合成
电泳剂
催化作用
试剂
化学
组合化学
反应条件
转化(遗传学)
立体化学
有机化学
生物化学
基因
作者
Yujing Zhou,Oliver D. Engl,Jeffrey S. Bandar,Emma D. Chant,Stephen L. Buchwald
标识
DOI:10.1002/anie.201802797
摘要
A CuH-catalyzed enantioselective hydroamidation reaction of vinylarenes has been developed using readily accessible 1,4,2-dioxazol-5-ones as electrophilic amidating reagents. This method provides a straightforward and efficient approach to synthesize chiral amides in good yields with high levels of enantiopurity under mild conditions. Moreover, this transformation tolerates substrates bearing a broad range of functional groups.
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