亚属
生物
同源(生物学)
病毒学
乳腺腺病毒
基因
核酸序列
血清型
遗传学
分子生物学
腺病毒科
分类学(生物学)
动物
遗传增强
作者
Patricia Pring‐Åkerblom,F.E. John Trijssenaar,Thomas E. Adrian
出处
期刊:Research in Virology
[Elsevier]
日期:1995-11-01
卷期号:146 (6): 383-388
被引量:19
标识
DOI:10.1016/0923-2516(96)80897-1
摘要
The hexon gene of human adenovirus (AV) type 7 (subgenus B) was sequenced. The determined nucleotide and the predicted amino acid sequences were compared to the corresponding sequences of AV3 and AV16. The hexons of AV7 and AV3 revealed an overall homology of 94.3% at the protein level, whereas the AV7 and AV16 hexons only showed an overall homology of 85.7%. Utilizing the three-dimensional model of the AV2 hexon, the structure of the AV7 hexon was predicted. The major differences between the three subgenus B hexon polypeptides were confined to the I1 and I2 surface loops. The AV7 I4 hexon loop was 100% identical to the other subgenus B I4 loops, but differed from the corresponding regions of other subgenera. This supports the idea that this loop carries a subgenus-specific determinant.
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