化学
芳基
立体化学
康布雷他汀
药物化学
细胞毒性
生物活性
IC50型
磺胺
细胞毒性T细胞
作者
Jie Zhou,Yi Zhang,Yi-Wen Cui,Zhan-mei Li,Hong-Rui Song,Jin-Hua Dong,Xiaoguang Chen,Bailing Xu
标识
DOI:10.1080/10286020.2011.556091
摘要
Two series of novel benzoimidazole sulfonamides as combretastatin A-4 analogs were synthesized. The cytotoxicities of the title compounds were evaluated against five different cancer cell lines. Among the tested compounds, four compounds displayed cytotoxicities against the HCT8 cell line. Compound 6a has shown the strongest potency against the tested human tumor cell lines with an IC₅₀ value ranging from submicromolar to micromolar level.
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