共感染
乙型肝炎病毒
线粒体毒性
医学
肝移植
乙型肝炎
移植
肝硬化
病毒学
胃肠病学
肝病
正庚病毒
肝炎
免疫学
毒性
七鳃鳗科
内科学
病毒
作者
Mariagrazia Tateo,Anne‐Marie Roque‐Afonso,Térésa Antonini,Fadia Medja,Anne Lombès,Claude Jardel,Elina Teicher,Mylène Sebagh,Bruno Roche,Denis Castaing,Didier Samuel,Jean‐Charles Duclos‐Vallée
出处
期刊:AIDS
[Ovid Technologies (Wolters Kluwer)]
日期:2009-06-01
卷期号:23 (9): 1069-1076
被引量:45
标识
DOI:10.1097/qad.0b013e32832c2a37
摘要
Background: In patients coinfected with hepatitis B virus (HBV) and human immunodeficiency virus (HIV), evolution toward cirrhosis and its complications is more rapid and severe than in patients infected with HBV alone. The outcome of liver transplantation in HBV–HIV-coinfected patients is poorly understood in terms of survival rate, HBV reactivation and mitochondrial toxicity on the liver graft. Patients and methods: Between November 2002 and June 2007, 13 HIV-positive patients underwent liver transplantation because of end-stage liver disease due to HBV with or without coinfection with hepatitis D or C virus. These patients were prospectively followed for an average of 32 ± 5.2 months (range 10–63 months). Results: All patients were alive at the end of the follow-up period and had normal liver function. Their HBV viral load was undetectable, no cccDNA was found in the liver graft and HIV infection was nonprogressive under antiretroviral therapy. Moreover, no mitochondrial toxicity was noted in the liver graft, as assessed by the spectrophotometric analysis of respiratory chain activities and by quantifying the mitochondrial DNA copy number. Conclusion: HBV–HIV-coinfected patients can successfully undergo liver transplantation with excellent results in terms of survival, control of HBV replication after transplantation and mitochondrial toxicity.
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