A new discussion of the cutaneous vascular reactivity in sensitive skin: A sub‐group of SS?

Abstract Background Sensitive skin (SS) seems not to be a one‐dimensional condition and many scholars concentrate on skin barrier disruption or sensorineural change, but few focus on its increased vascular reactivity. This study explored the possibility of using the different selection methods and measurement methods to verify a high vascular reactivity in SS without an impaired cutaneous barrier function. Methods Sixty “self‐perceived sensitive skin” volunteers were enlisted and each one completed three kinds of screening tests: assess cutaneous sensory using questionnaire survey and Lactic Acid Sting Test (LAST); assess barrier function using Sodium lauryl sulphate (SLS) skin irritation test and assess cutaneous vascular reactivity using 98% DMSO test and non‐invasive measurement. Volunteers were divided into different groups based on response to SLS. The DMSO clinical score and the biophysical parameters obtained by non‐invasive measurement were subsequently analysed. Results (1) The positive correlations could be seen between sum LAST score and sum DMSO score regardless of the observation time; (2) The biological parameters (CBF、 a *values and L * values) are all keeping with DMSO score; (3) If the participants were divided into SLS reactors and non‐reactors, a composition ratio of DMSO score was significant difference in these two groups and in SLS non‐reactors, there were still seven participants showed high reaction to DMSO. Conclusions There is a sub‐group of SS for characteristics of a high vascular reactivity without an impaired cutaneous barrier function. The DMSO test and novel non‐invasive measurements which are conducive to assess cutaneous vascular reactivity, combined with SLS skin irritation test could help us to screen this kind of SS.