感觉加工
神经科学
感觉系统
心理学
体感系统
运动前皮质
任务(项目管理)
感知
感觉皮层
认知心理学
筒状皮质
生物
背
管理
经济
解剖
作者
Giulio Matteucci,Maëlle Guyoton,Johannes M. Mayrhofer,Matthieu Auffret,Georgios Foustoukos,Carl C.H. Petersen,Sami El-Boustani
出处
期刊:Neuron
[Elsevier]
日期:2022-10-01
标识
DOI:10.1016/j.neuron.2022.09.032
摘要
Summary
Behavioral states can influence performance of goal-directed sensorimotor tasks. Yet, it is unclear how altered neuronal sensory representations in these states relate to task performance and learning. We trained water-restricted mice in a two-whisker discrimination task to study cortical circuits underlying perceptual decision-making under different levels of thirst. We identified somatosensory cortices as well as the premotor cortex as part of the circuit necessary for task execution. Two-photon calcium imaging in these areas identified populations selective to sensory or motor events. Analysis of task performance during individual sessions revealed distinct behavioral states induced by decreasing levels of thirst-related motivation. Learning was better explained by improvements in motivational state control rather than sensorimotor association. Whisker sensory representations in the cortex were altered across behavioral states. In particular, whisker stimuli could be better decoded from neuronal activity during high task performance states, suggesting that state-dependent changes of sensory processing influence decision-making.
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