苯硼酸
芳基
草酸
催化作用
化学
钯
一氧化碳
有机化学
聚苯乙烯
组合化学
聚合物
烷基
作者
Pushkar Mehara,Poonam Sharma,Ajay Sharma,- Shaifali,Pralay Das
标识
DOI:10.1016/j.mcat.2023.113546
摘要
Polystyrene supported palladium (Pd@PS) catalyzed cost-efficient and sustainable protocol for carbonylative Suzuki-Miyaura cross-coupling (C-SMCC) reaction has been reported. Herein, ppm (parts per million) level of Pd (0.1 mol%, 1000 ppm) of the Pd@PS catalyst, with high turnover number, i.e. ∼5061 (calculated upto six cycles) was applied. Furthermore, to avoid the direct use of toxic, flammable, odorless carbon monoxide (CO) gas, oxalic acid has been applied as solid, inexpensive, additive-free CO source. The developed protocol is applicable to wide range of aryl iodides and phenylboronic acids that produce symmetrical and unsymmetrical biaryl ketones. Interestingly, di-carbonylative Suzuki-Miyaura cross-coupling products were also obtained in moderate to excellent yields.
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