血管生成素受体
血管生成
受体酪氨酸激酶
血管生成素
生物
血管生成素2
转基因小鼠
癌症研究
新生血管
细胞生物学
体内
酪氨酸激酶
受体
调节器
血管内皮生长因子
内分泌学
医学
周细胞
内科学
血管内皮生长因子A
血管通透性
转基因
激酶
信号转导
生物化学
基因
血管内皮生长因子受体
作者
Peter C. Maisonpierre,Chitra Suri,Pamela F. Jones,Sona Bartunkova,Stanley J. Wiegand,Czeslaw Radziejewski,Debra L Compton,Joyce McClain,Thomas H. Aldrich,Nick Papadopoulos,Thomas J. Daly,Samuel Davis,Thomas N. Sato,George D. Yancopoulos
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:1997-07-04
卷期号:277 (5322): 55-60
被引量:3226
标识
DOI:10.1126/science.277.5322.55
摘要
Angiogenesis is thought to depend on a precise balance of positive and negative regulation. Angiopoietin-1 (Ang1) is an angiogenic factor that signals through the endothelial cell–specific Tie2 receptor tyrosine kinase. Like vascular endothelial growth factor, Ang1 is essential for normal vascular development in the mouse. An Ang1 relative, termed angiopoietin-2 (Ang2), was identified by homology screening and shown to be a naturally occurring antagonist for Ang1 and Tie2. Transgenic overexpression of Ang2 disrupts blood vessel formation in the mouse embryo. In adult mice and humans, Ang2 is expressed only at sites of vascular remodeling. Natural antagonists for vertebrate receptor tyrosine kinases are atypical; thus, the discovery of a negative regulator acting on Tie2 emphasizes the need for exquisite regulation of this angiogenic receptor system.
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