Host-guest inclusion systems of mangiferin and polyamine-β-cyclodextrins: Preparation, characterization and anti-cancer activity

This paper reports host-guest inclusion systems of mangiferin (MGF) with four polyamine-modified β-cyclodextrins (PAβCDs). The inclusion complexes have been characterized by 1D and 2D nuclear magnetic resonance (NMR), thermal gravimetric analysis (TGA), X-ray powder diffraction (XRD) and scanning electron microscopy (SEM). The results show that MGF was encapsulated into the cavities of PAβCDs to form four complexes with 1:1 stoichiometry. The water solubility of the complexes was enhanced markedly, and the cytotoxicity of these complexes to normal cell line HEK293 was significantly reduced in comparison with native MGF. This satisfactory water solubilization and improvement of cytotoxicity with MGF/PAβCDs complexes will be potentially useful for its application as herbal medicine or healthcare products.