造血
生物
血管生成
癌症研究
免疫系统
免疫学
转录因子
干细胞
恶性转化
背景(考古学)
插入突变
细胞生物学
遗传学
祖细胞
基因
古生物学
基因组
作者
Yaacov Ben‐David,Babu Gajendran,Klarke M. Sample,Eldad Zacksenhaus
标识
DOI:10.1007/s00018-022-04160-1
摘要
Fli-1, a member of the ETS family of transcription factors, was discovered in 1991 through retroviral insertional mutagenesis as a driver of mouse erythroleukemias. In the past 30 years, nearly 2000 papers have defined its biology and impact on normal development and cancer. In the hematopoietic system, Fli-1 controls self-renewal of stem cells and their differentiation into diverse mature blood cells. Fli-1 also controls endothelial survival and vasculogenesis, and high and low levels of Fli-1 are implicated in the auto-immune diseases systemic lupus erythematosus and systemic sclerosis, respectively. In addition, aberrant Fli-1 expression is observed in, and is essential for, the growth of multiple hematological malignancies and solid cancers. Here, we review the historical context and latest research on Fli-1, focusing on its role in hematopoiesis, immune response, and malignant transformation. The importance of identifying Fli-1 modulators (both agonists and antagonists) and their potential clinical applications is discussed.
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