前药
阿霉素
化疗
膀胱癌
药物输送
药品
药理学
细胞内
癌症
化学
纳米技术
癌症研究
医学
材料科学
内科学
生物化学
作者
Da‐Yong Hou,Ni-Yuan Zhang,Man‐Di Wang,Shaoxin Xu,Zhijia Wang,Xiaofang Hu,Gan-Tian Lv,Jiaqi Wang,Xiu-Hai Wu,Lu Wang,Dong‐Bing Cheng,Hao Wang,Wanhai Xu
标识
DOI:10.1002/anie.202116893
摘要
Intravesical administration of first-line drugs has shown failure in the treatment of bladder cancer owing to the poor tumor retention time of chemotherapeutics. Herein, we report an intracellular hydrolytic condensation (IHC) system to construct long-term retentive nano-drug depots in situ, wherein sustained drug release results in highly efficient suppression of bladder cancer. Briefly, the designed doxorubicin (Dox)-silane conjugates self-assemble into silane-based prodrug nanoparticles, which condense into silicon particle-based nano-drug depots inside tumor cells. Significantly, we demonstrate that the IHC system possesses highly potent antitumor efficacy, which leads to the regression and eradication of large established tumors and simultaneously extends the overall survival of air pouch bladder cancer mice compared with that of mice treated with Dox. The concept of intracellular hydrolytic condensation can be extended via conjugating other chemotherapeutic drugs, which may facilitate rational design of novel nanomedicines for augmentation of chemotherapy.
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