ASYMMETRIC NUCLEOPHILIC ADDITION TO KETONES AND KETIMINES AND CONJUGATE ADDITION REACTIONS

Catalytic asymmetric nucleophilic additions to carbonyls and imines, as well as conjugate additions to Michael acceptors are powerful methods for carbon-carbon bond formation. Applications for a variety of nucleophiles have been reported in the past few years. This chapter surveys the most recent developments with a particular focus on work using non-stabilized nucleophiles, such as organomagnesium (Grignard), organozinc, organoboron, organozirconium, and organotitanium reagents. The literature from the last five years is covered, with a selection of important references from before 2015 included as background information. The chapter is divided into three parts: (i) asymmetric nucleophilic addition to ketones, (ii) asymmetric nucleophilic addition to ketimines, and (iii) asymmetric conjugate addition reactions.