催化作用
化学
活性氧
抗氧化剂
生物分子
合理设计
水溶液中的金属离子
羟基自由基
组合化学
金属
纳米技术
材料科学
有机化学
生物化学
作者
Fei Xu,Yonghua Tang,Hao Wang,Hongbo Deng,Yanyan Huang,Chaoyu Fan,Jiachen Zhao,Changxu Lin,Youhui Lin
出处
期刊:Small
[Wiley]
日期:2022-05-11
卷期号:18 (23)
被引量:13
标识
DOI:10.1002/smll.202201205
摘要
Self-assembled nanostructures based on biomolecules (e.g., proteins and amino acids) and metal ions have promising applications in mimicking the nanostructure, properties, and functions of natural enzymes. Herein, a metal ion-mediated self-assembly method for constructing catalytically active Cu-wool-keratin (CuWK) two-dimensional nanozymes is presented. Specifically, by introducing copper ions as abiological cofactors, WK can serve as a protein scaffold to design and create Cu catalytic sites. The optimized hybrids with Cu-WK coordination framework exhibit significant superoxide dismutases-like activity, catalase-like activity, and hydroxyl radical scavenging ability. These combined antioxidant activities make CuWK a robust nanozyme to effectively remove various reactive oxygen species (ROS). In this work, the as-prepared CuWK as a new additive can be integrated into a cigarette filter system to effectively remove the produced ROS from the burning of tobacco. More importantly, the CuWK nanozymes as a critical element can be further utilized to construct a recycling cigarette holder. Therefore, the present work shows that nanozymes with advanced catalytic capabilities can be constructed by self-assembly of metal ions and proteins, thus facilitating the rational design and discovery of this kind of artificial metalloenzymes.
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