衰老
细胞凋亡
端粒
生物
免疫学
归巢(生物学)
CD8型
记忆T细胞
细胞生物学
T细胞
肿瘤坏死因子α
效应器
免疫系统
遗传学
DNA
生态学
作者
Sudhir Gupta,Sastry Gollapudi
标识
DOI:10.1016/j.autrev.2005.09.007
摘要
Aging in humans is associated with progressive decline in T cell function, hyperimmunoglobulinemia, increased prevalence of autoantibodies and decline in naïve CD8(+) T cells and accumulation of memory T cells, which appears to be oligoclonal and display feature of senescence, that is, decreased replication, short telomere length and resistance to apoptosis. Recently memory T cells have been further subdivided into central and effector memory T cells, based upon their migratory and homing properties. They are identified by a number of cell surface makers. In this brief review we will discuss molecular mechanisms of apoptosis in naïve and various types of memory T cells to possibly explain the changes observed in aging, which are very similar to certain autoimmune diseases.
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