弓形虫
免疫系统
细胞内寄生虫
生物
微生物学
使负有责任或义务
寄生虫寄主
脂多糖
细菌
专性寄生虫
免疫
寄主(生物学)
免疫学
病毒学
抗体
遗传学
万维网
计算机科学
生态学
作者
Dominique Buzoni‐Gatel,Catherine Werts
标识
DOI:10.1016/j.pt.2006.08.002
摘要
Toxoplasma gondii is an intracellular obligate parasite that enters the host via the gastrointestinal tract. The parasite is able to evade or subvert the immune response of its host via various mechanisms. Here, we discuss a recent in vitro study by Eric Denkers and colleagues that focused on the modulation of gene transcription of host macrophages stimulated by lipopolysaccharide (LPS) following infection with T. gondii. The parasite was able to block the response of macrophages to LPS, a major immunostimulatory component of Gram negative bacteria, thus possibly avoiding the hyperinflammatory response of the host to gut microflora, among which Gram negative bacteria are abundant.
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