Effects of food intake on pharmacokinetics of mosapride in beagle dogs

This study was performed to determine the pharmacokinetic profile of mosapride in fasting and fed states. A single 5‐mg oral dose of mosapride was administered to fasted ( n = 15) and fed ( n = 12) beagle dogs, and the plasma concentrations of mosapride were measured by liquid chromatography–tandem mass spectrometry. The resultant data were analyzed by noncompartmental analysis ( NCA ). Mosapride was absorbed in fasted and fed dogs with similar T max . Both C max and AUC were significantly higher in the fasting group than in fed dogs, being four times (10.51 μg/ mL vs. 2.76 μg/ mL ) and 3.5 times higher (38.53 h·μg/ mL vs. 10.22 h·μg/ mL ), respectively. These findings suggest that food intake affects the pharmacokinetics of mosapride and that the dosage regimen for this drug need to be reconsidered.