结缔组织
医学
肺动脉高压
内科学
生物标志物
生长因子
心脏病学
结缔组织病
胃肠病学
病理
生物
生物化学
受体
自身免疫性疾病
疾病
作者
Eslam Hella,Doaa El Amrousy,Hesham El-Serogy,Amr Zoair
出处
期刊:Cardiology in The Young
[Cambridge University Press]
日期:2020-03-31
卷期号:30 (4): 533-538
被引量:3
标识
DOI:10.1017/s104795112000058x
摘要
Abstract Objective: To evaluate the diagnostic and predictive values of plasma connective tissue growth factor in children with pulmonary hypertension (PH)-related CHD. Patients and methods: Forty patients with PH-related CHD were enrolled as group I, and 40 patients with CHD and no PH served as group II. Forty healthy children of matched age and sex served as a control group. Echocardiographic examinations and plasma connective tissue growth factor levels were performed for all included children. Cardiac catheterisation was performed for children with CHD only. Results: Plasma connective tissue growth factor levels were significantly higher in children with PH-related CHD compared to CHD-only patients and to control group and this elevation went with the severity of PH. There was a significant positive correlation between connective tissue growth factor levels and mean pulmonary pressure, pulmonary vascular resistance, and right ventricular diameter. A significant negative correlation was noticed between connective tissue growth factor levels, oxygen saturation, and right ventricular diastolic function. The sensitivity of plasma connective tissue growth factor as a diagnostic biomarker for PH was 95%, and the specificity was 90% at a cut-off value ≥650 pg/mL. The predictive value of plasma connective tissue growth factor for adverse outcome had a sensitivity of 88% and a specificity of 83% at a cut-off value ≥1900 pg/mL. Conclusion: Connective tissue growth factor is a promising biomarker with good diagnostic and predictive values in children with PH-related CHD.
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