肠易激综合征
医学
优势比
置信区间
生活质量(医疗保健)
可能性
人口学
年轻人
功能性胃肠病
家庭医学
老年学
精神科
内科学
逻辑回归
护理部
社会学
作者
Ami D. Sperber,Shrikant I. Bangdiwala,Douglas A. Drossman,Uday C Ghoshal,Magnus Simrén,Jan Tack,William E. Whitehead,Dan L. Dumitraşcu,Xiangqun Fang,Shin Fukudo,John Kellow,Edith Okeke,Eamonn M.M. Quigley,Max Schmulson,Peter J. Whorwell,Timothy Archampong,Payman Adibi,Viola Andresen,Marc A. Benninga,Bruno Bonaz,Serhat Bor,Lidia Fernández,Suck Chei Choi,Enrico Corazziari,Carlos Fernando de Magalhães Francisconi,Albis Hani,Л. Б. Лазебник,Yeong Yeh Lee,Agata Mulak,Mohammed M. Rahman,Javier Santos,Mashiko Setshedi,Ari Fahrial Syam,Stephen Vanner,Reuben K. Wong,Aurelio López‐Colombo,Valéria Costa,Ram Dickman,Motoyori Kanazawa,Ammar Hassanzadeh Keshteli,Rutaba Khatun,Iradj Maleki,Pierre Poitras,Nitesh Pratap,Oksana Stefanyuk,Sandie Thomson,Judith Zeevenhooven,Olafur S. Palsson
标识
DOI:10.1053/j.gastro.2020.04.014
摘要
Background & AimsAlthough functional gastrointestinal disorders (FGIDs), now called disorders of gut-brain interaction, have major economic effects on health care systems and adversely affect quality of life, little is known about their global prevalence and distribution. We investigated the prevalence of and factors associated with 22 FGIDs, in 33 countries on 6 continents.MethodsData were collected via the Internet in 24 countries, personal interviews in 7 countries, and both in 2 countries, using the Rome IV diagnostic questionnaire, Rome III irritable bowel syndrome questions, and 80 items to identify variables associated with FGIDs. Data collection methods differed for Internet and household groups, so data analyses were conducted and reported separately.ResultsAmong the 73,076 adult respondents (49.5% women), diagnostic criteria were met for at least 1 FGID by 40.3% persons who completed the Internet surveys (95% confidence interval [CI], 39.9–40.7) and 20.7% of persons who completed the household surveys (95% CI, 20.2–21.3). FGIDs were more prevalent among women than men, based on responses to the Internet survey (odds ratio, 1.7; 95% CI, 1.6–1.7) and household survey (odds ratio, 1.3; 95% CI, 1.3–1.4). FGIDs were associated with lower quality of life and more frequent doctor visits. Proportions of subjects with irritable bowel syndrome were lower when the Rome IV criteria were used, compared with the Rome III criteria, in the Internet survey (4.1% vs 10.1%) and household survey (1.5% vs 3.5%).ConclusionsIn a large-scale multinational study, we found that more than 40% of persons worldwide have FGIDs, which affect quality of life and health care use. Although the absolute prevalence was higher among Internet respondents, similar trends and relative distributions were found in people who completed Internet vs personal interviews. Although functional gastrointestinal disorders (FGIDs), now called disorders of gut-brain interaction, have major economic effects on health care systems and adversely affect quality of life, little is known about their global prevalence and distribution. We investigated the prevalence of and factors associated with 22 FGIDs, in 33 countries on 6 continents. Data were collected via the Internet in 24 countries, personal interviews in 7 countries, and both in 2 countries, using the Rome IV diagnostic questionnaire, Rome III irritable bowel syndrome questions, and 80 items to identify variables associated with FGIDs. Data collection methods differed for Internet and household groups, so data analyses were conducted and reported separately. Among the 73,076 adult respondents (49.5% women), diagnostic criteria were met for at least 1 FGID by 40.3% persons who completed the Internet surveys (95% confidence interval [CI], 39.9–40.7) and 20.7% of persons who completed the household surveys (95% CI, 20.2–21.3). FGIDs were more prevalent among women than men, based on responses to the Internet survey (odds ratio, 1.7; 95% CI, 1.6–1.7) and household survey (odds ratio, 1.3; 95% CI, 1.3–1.4). FGIDs were associated with lower quality of life and more frequent doctor visits. Proportions of subjects with irritable bowel syndrome were lower when the Rome IV criteria were used, compared with the Rome III criteria, in the Internet survey (4.1% vs 10.1%) and household survey (1.5% vs 3.5%). In a large-scale multinational study, we found that more than 40% of persons worldwide have FGIDs, which affect quality of life and health care use. Although the absolute prevalence was higher among Internet respondents, similar trends and relative distributions were found in people who completed Internet vs personal interviews.