抗原
嵌合抗原受体
癌症研究
启动(农业)
生物
细胞毒性T细胞
医学
免疫学
胶质瘤
T细胞
免疫系统
体外
生物化学
植物
发芽
作者
Joseph Choe,Payal Watchmaker,Milos Simic,Ryan Gilbert,Aileen W. Li,Nira A. Krasnow,Kira Downey,Wei Yu,Diego Carrera,Anna Celli,Juhyun Cho,Jessica Briones,Jason Duecker,Yitzhar Goretsky,Ruth Dannenfelser,Lia Cardarelli,Olga G. Troyanskaya,Sachdev S. Sidhu,Kole T. Roybal,Hideho Okada
标识
DOI:10.1126/scitranslmed.abe7378
摘要
SynNotch-CAR T cells durably clear glioblastoma xenografts, overcoming dual challenges of antigen heterogeneity and specificity common to solid tumors.
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