上睑下垂
败血症
机制(生物学)
炎症
医学
主机响应
炎症体
促炎细胞因子
免疫学
免疫系统
重症监护医学
认识论
哲学
作者
Xiangtao Zheng,Weiwei Chen,Fangchen Gong,Ying Chen,Erzhen Chen
标识
DOI:10.3389/fimmu.2021.711939
摘要
Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host response to infection. Recently was been found that pyroptosis is a unique form of proinflammatory programmed death, that is different from apoptosis. A growing number of studies have investigated pyroptosis and its relationship with sepsis, including the mechanisms, role, and relevant targets of pyroptosis in sepsis. While moderate pyroptosis in sepsis can control pathogen infection, excessive pyroptosis can lead to a dysregulated host immune response and even organ dysfunction. This review provides an overview of the mechanisms and potential therapeutic targets underlying pyroptosis in sepsis identified in recent decades, looking forward to the future direction of treatment for sepsis.
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