化学
外消旋化
环加成
组合化学
试剂
四唑
芳香性
有机化学
分子
催化作用
作者
Kotaro Ishihara,Kazuki Ishihara,Yota Tanaka,Takayuki Shioiri,Masato Matsugi
出处
期刊:Tetrahedron
[Elsevier]
日期:2022-02-01
卷期号:108: 132642-132642
被引量:8
标识
DOI:10.1016/j.tet.2022.132642
摘要
Tetrazoles were effectively synthesized from amides using diphenyl phosphorazidate or bis(p-nitrophenyl) phosphorazidate in the presence of aromatic bases. Various amides underwent the proposed cycloaddition reaction to provide the corresponding tetrazoles. Studies on the racemization of chiral substrates were also performed. Overall, the proposed synthesis method enables the preparation of 1,5-disubstituted and 1-substituted tetrazoles, and 5-substituted 1H-tetrazoles without using toxic or explosive reagents.
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