医学
剖腹探查术
恶心
外科
胃切除术
白细胞减少症
癌症
化疗
腺癌
中性粒细胞减少症
围手术期
放化疗
表阿霉素
内科学
环磷酰胺
作者
Xiaowen Liu,Guichao Li,Ziwen Long,Jiliang Yin,Xiaodong Zhu,Weiqi Sheng,Dan Huang,Hui Zhu,Zhaozhen Zhang,Hong Cai,Hua Huang,Guangfa Zhao,Ye Zhou,Zhen Zhang,Yanong Wang
摘要
Background and Purpose The ideal treatment strategy of patients with locally advanced gastric adenocarcinoma is unclear. The aim of this study is to evaluate the efficacy and feasibility of preoperative chemoradiation in these patients. Patients and Methods All patients underwent laparoscopic exploration or exploratory laparotomy before chemoradiation. Patients received one cycle of S‐1 and oxalipatin followed by concurrent radiation and chemotherapy, then underwent another cycle of S‐1 and oxalipatin. Surgery was performed 6‐8 weeks after completing radiochemotherapy. The rate of curative gastrectomy and survival were investigated. This trial was registered with ClinicalTrial.gov , number NCT02024217. Results From April 2012 to August 2014, 40 patients were enrolled in the trial, and 36 patients were assessable. The most common hematologic toxic effects were leukopenia (80.6%), neutropenia (69.4%), and thrombocytopenia (50%); the most common nonhematologic toxic effects were anorexia (50%), nausea (22.3%), and vomiting (13.9%). There were no treatment related deaths. A total of 33 patients underwent second exploratory laparotomy after preoperative chemoradiation, and 24 (67%) patients received curative gastrectomy. The rates of pathological complete response (pCR) were 13.9%. The medial survival time (MST) was 30.3 months. Conclusion Preoperative chemoradiation may be an effective treatment strategy among patients with locally advanced gastric adenocarcinoma.
科研通智能强力驱动
Strongly Powered by AbleSci AI