神经发生
生物
神经科学
细胞命运测定
视网膜
祖细胞
视网膜
转录因子
干细胞
细胞生物学
遗传学
基因
生物化学
作者
Xin Zhang,Patrick J. Leavey,Haley Appel,Neoklis Makrides,Seth Blackshaw
标识
DOI:10.1016/j.tig.2023.06.002
摘要
This review covers recent advances in understanding the molecular mechanisms controlling neurogenesis and specification of the developing retina, with a focus on insights obtained from comparative single cell multiomic analysis. We discuss recent advances in understanding the mechanisms by which extrinsic factors trigger transcriptional changes that spatially pattern the optic cup (OC) and control the initiation and progression of retinal neurogenesis. We also discuss progress in unraveling the core evolutionarily conserved gene regulatory networks (GRNs) that specify early- and late-state retinal progenitor cells (RPCs) and neurogenic progenitors and that control the final steps in determining cell identity. Finally, we discuss findings that provide insight into regulation of species-specific aspects of retinal patterning and neurogenesis, including consideration of key outstanding questions in the field.
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