嵌合抗原受体
免疫疗法
免疫系统
免疫学
T细胞
癌症免疫疗法
抗原
计算生物学
医学
生物
作者
Iowis Zhu,Dan I. Piraner,Kole T. Roybal
出处
期刊:Cancer immunology research
[American Association for Cancer Research]
日期:2023-07-10
卷期号:11 (8): 1030-1043
标识
DOI:10.1158/2326-6066.cir-22-0962
摘要
The immune system includes an array of specialized cells that keep us healthy by responding to pathogenic cues. Investigations into the mechanisms behind immune cell behavior have led to the development of powerful immunotherapies, including chimeric-antigen receptor (CAR) T cells. Although CAR T cells have demonstrated efficacy in treating blood cancers, issues regarding their safety and potency have hindered the use of immunotherapies in a wider spectrum of diseases. Efforts to integrate developments in synthetic biology into immunotherapy have led to several advancements with the potential to expand the range of treatable diseases, fine-tune the desired immune response, and improve therapeutic cell potency. Here, we examine current synthetic biology advances that aim to improve on existing technologies and discuss the promise of the next generation of engineered immune cell therapies.
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