微泡
癌症干细胞
肿瘤微环境
免疫系统
癌症研究
干细胞
癌症
免疫疗法
癌细胞
癌症免疫疗法
生物
免疫学
医学
小RNA
细胞生物学
基因
生物化学
遗传学
作者
Dongyu Li,Lei Wang,Bo Jiang,Yuchen Jing,Xuan Li
标识
DOI:10.1016/j.biopha.2023.116043
摘要
Cancer stem cells are the key link between malignant tumor progression and drug resistance. This cell population has special properties that are different from those of conventional tumor cells, and the role of cancer stem cell-related exosomes in progression of tumor malignancy is becoming increasingly clear. Cancer stem cell-derived exosomes carry a variety of functional molecules involved in regulation of the microenvironment, especially with regard to immune cells, but how these exosomes exert their functions and the specific mechanisms need to be further clarified. Here, we summarize the role of cancer stem cell exosomes in regulating immune cells in detail, aiming to provide new insights for subsequent targeted drug development and clinical strategy formulation.
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