狼牙棒
冠状动脉疾病
内科学
医学
心脏病学
造血
血液学
心肌梗塞
生物
肿瘤科
干细胞
遗传学
经皮冠状动脉介入治疗
作者
Mihaela Ioana Dregoesc,Helin Tercan,Adrian Bogdan Țigu,Siroon Bekkering,Leo A. B. Joosten,Mihai G. Netea,Rosanne C. van Deuren,Alexander Hoischen,Niels P. Riksen,Adrian Corneliu Iancu
出处
期刊:iScience
[Elsevier]
日期:2024-03-01
卷期号:: 109472-109472
标识
DOI:10.1016/j.isci.2024.109472
摘要
Clonal hematopoiesis (CH) is a risk factor for atherosclerotic cardiovascular disease, but the impact of smaller clones and the effect on inflammatory parameters is largely unknown. Using ultrasensitive single-molecule molecular inversion probe sequencing, we evaluated the association between CH and a first major adverse cardiovascular event (MACE) in patients with angiographically documented stable coronary artery disease (CAD) and no history of acute ischemic events. CH was associated with an increased rate of MACE at four years follow-up. The size of the clone predicted MACE at an optimal cut-off value of 1.07% variant allele frequency (VAF). Mutation carriers had no change in monocytes subsets or cytokine production capacity but had higher levels of circulating tissue factor, matrilysin, and proteinase-activated receptor-1. Our study identified CH driver mutations with a VAF as small as 1.07% as a residual cardiovascular risk factor and identified potential biomarkers and therapeutic targets for patients with stable CAD.
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