免疫疗法
医学
头颈部鳞状细胞癌
癌症研究
免疫学
癌症免疫疗法
头颈部癌
主要组织相容性复合体
肺癌
刘易斯肺癌
癌症
病理
抗原
免疫系统
转移
内科学
作者
Dianne Khurana,Elizabeth A. Martin,Jan L. Kasperbauer,Bert W. O’Malley,Diva R. Salomão,Lieping Chen,Scott E. Strome
出处
期刊:Head & neck
[Wiley]
日期:2001-09-06
卷期号:23 (10): 899-906
被引量:90
摘要
Abstract Background To develop novel therapeutic approaches for patients with head and neck malignancies, poorly immunogenic murine models of squamous cell carcinoma (SCC) need to be defined. Methods The phenotype, growth characteristics, and responsiveness to tumor‐specific T‐cell transfer of a spontaneously arising murine SCC (SCC VII) were characterized. Results SCC VII expresses major histocompatibility complex (MHC) class I molecules yet is resistant to tumor‐specific T‐cell killing and relatively insensitive to killing mediated by lymphokine‐activated killer (LAK) cells. Intradermal tumors are reproducibly established after vaccination of 5 × 10 4 cells, and systemic micrometastases are apparent after intravenous administration of 2.5 × 10 4 cells. Immunotherapy of 3‐day lung metastases using tumor‐specific T cells and systemic interleukin‐2 (IL‐2) was ineffective in reducing the number of metastases in vivo. Conclusions SCC VII is a poorly immunogenic murine squamous cell cancer, which represents an ideal model for preclinical testing of immunotherapeutic approaches for patients with SCC of the upper aerodigestive tract. © 2001 John Wiley & Sons, Inc. Head Neck 23: 899–906, 2001.
科研通智能强力驱动
Strongly Powered by AbleSci AI