溶血磷脂酰胆碱
Jurkat细胞
内化
自身免疫性疾病
受体
细胞生物学
自身免疫
生物
免疫系统
蛋白激酶A
MAPK/ERK通路
信号转导
免疫学
T细胞
激酶
生物化学
抗体
磷脂
膜
磷脂酰胆碱
作者
Janusz H. Kabarowski,Kui Zhu,Lu Q. Le,Owen N. Witte,Yan Xu
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:2001-07-27
卷期号:293 (5530): 702-705
被引量:302
标识
DOI:10.1126/science.1061781
摘要
Although the biological actions of the cell membrane and serum lipid lysophosphatidylcholine (LPC) in atherosclerosis and systemic autoimmune disease are well recognized, LPC has not been linked to a specific cell-surface receptor. We show that LPC is a high-affinity ligand for G2A, a lymphocyte-expressed G protein-coupled receptor whose genetic ablation results in the development of autoimmunity. Activation of G2A by LPC increased intracellular calcium concentration, induced receptor internalization, activated ERK mitogen-activated protein kinase, and modified migratory responses of Jurkat T lymphocytes. This finding implicates a role for LPC-G2A interaction in the etiology of inflammatory autoimmune disease and atherosclerosis.
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