达布科
热重分析
核化学
化学
药物输送
金属有机骨架
扫描电子显微镜
吸附
粉末衍射
辛烷值
材料科学
有机化学
结晶学
复合材料
作者
Negar Motakef-Kazemi,Seyed Abbas Shojaosadati,Ali Morsali
标识
DOI:10.1016/j.micromeso.2013.11.036
摘要
In the present study, in situ synthesis of a drug-loaded metal–organic framework (MOF) was accomplished at room temperature. The produced drug-loaded MOF [{Zn2(1,4-bdc)2(dabco)}n] was then studied as a drug delivery system and exhibited the ability to entrap ibuprofen model drug. The ibuprofen loading efficiency of the MOF was 15% (w/w) in the selected synthesis conditions. The drug release was also monitored and 80% of the loaded drug was released over 12 days. The MOF was characterized by IR spectroscopy, X-ray powder diffraction (XRD), thermogravimetric analysis (TGA), UV–vis spectroscopy, N2 adsorption porosimetric (BET), and field emission scanning electron microscopy (FE-SEM). The IC50 value, cytotoxicity, of Zn2(1,4-bdc)2(dabco) for human Hepatoma cell (HuH7) was determined to be 1 mg/ml by MTT assay.
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