毛发生长
毛囊
黑色素
头发周期
生物
表皮(动物学)
免疫组织化学
传统医学
药理学
免疫学
内分泌学
医学
生物化学
生理学
解剖
作者
Kakali Datta,Anu Singh,A Mukherjee,B. K. Bhat,B. Ramesh,Anand C. Burman
标识
DOI:10.1016/j.jep.2009.05.023
摘要
Ethnopharmacological relevance: Eclipta alba is traditionally known to potentiate hair growth promotion. The study was aimed to investigate the efficacy of methanol extract of Eclipta alba as hair growth promoter. Pigmented C57/BL6 mice, preselected for their telogen phase of hair growth were used. In these species, the truncal epidermis lacks melanin-producing melanocytes and melanin production is strictly coupled to anagen phase of hair growth. The extract was applied topically to assess telogen to anagen transition. Immunohistochemical investigation was performed to analyze antigen specificity. Animals in anagen phase of hair growth were positive for FGF-7 and Shh and negative for BMP4, whereas the animals in telogen phase were positive only for BMP4 antigen. The methanol extract of whole plant when tested for hair growth promoting potential, exhibited dose dependent activity in C57BL6 mice. The activity was assessed by studying the melanogenesis in resected skin, follicle count in the subcutis, skin thickness and surrogate markers in vehicle control and extract treated animals. These findings suggest that methanol extract of Eclipta alba may have potential as a hair growth promoter.
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