Functional magnetic resonance imaging identifies somatotopic organization of nociception in the human spinal cord

功能磁共振成像 脊髓 伤害 医学 神经科学 血氧水平依赖性 鱼际隆起 体感系统 磁共振成像 刺激 人脑 解剖 心理学 放射科 受体 内科学
作者
Penelope Nash,Katherine Wiley,Justin Brown,Richard Shinaman,David Ludlow,Alice T. Sawyer,Gary H. Glover,Sean Mackey
出处
期刊:Pain [Lippincott Williams & Wilkins]
卷期号:154 (6): 776-781 被引量:37
标识
DOI:10.1016/j.pain.2012.11.008
摘要

This study found lateralized and somatotopically appropriate activation in the human spinal cord during acute heat pain applied to 2 separate dermatomes. Functional magnetic resonance imaging (fMRI) is a technique that uses blood oxygen–level–dependent (BOLD) signals to elucidate discrete areas of neuronal activity. Despite the significant number of fMRI human brain studies, few researchers have applied fMRI technology to investigating neuronal activity within the human spinal cord. Our study goals were to demonstrate that fMRI could reveal the following: (i) appropriate somatotopic activations in response to noxious stimuli in the deep and superficial dorsal horn of the human cervical spinal cord, and (ii) lateralization of fMRI activations in response to noxious stimulation in the right and left upper extremity. We subjected healthy participants to noxious stimulation during fMRI scans. Using a spiral in–out image sequence and retrospective correction for physiologic noise, we demonstrated that fMRI can create high-resolution, neuronal activation maps of the human cervical spinal cord. During nociceptive stimulation of all 4 sites (left deltoid, right deltoid, left thenar eminence and right thenar eminence), we found ipsilateral dorsal horn activation. Stimulation of the deltoid activated C5, whereas stimulation of the thenar eminence activated C6. Our study contributes to creating an objective analysis of pain transmission; other investigators can use these results to further study central nervous system changes that occur in patients with acute and chronic pain.
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