P677 Gasdermin B (GSDMB) is implicated as a contributor to IBD susceptibility

Poster presentations desert was also associated with perianal disease (rs10092418, p = 8×10 6 ).Conclusions: We report novel genetic and serologic associations with perianal disease in a large cohort of Crohn's disease patients.The association between perianal disease and a locus near MYC, which encodes a transcription factor with broad activity in cell proliferation, apoptosis, and differentiation, suggests novel mechanisms in the development of perianal disease.Replication will be important to confirm findings and direct further investigation into this unique Crohn's disease phenotype.