Pharmacokinetic of Behaviors Transdermal Delivery and Oral Administration of Cyclosporin A Preparations in Mice

The study was to investigate the pharmacokinetic behaviors of cyclosporin A in mice by transdermal delivery of flexible liposomes and oral administration of the marketed preparation. Time courses of drug concentration in blood, kidney and skin were determined after application of flexible liposomes onto the mice skin non-occlusively. Pharmacokinetic behaviors were compared with those in oral administration of Sandimmun Neoral ○R . The relative bioavailability of transdermal delivery versus oral administration was (82.51±5.45)%. The ratio of AUC in kidney was (150.6±15.62)%. Flexible liposomes deposited much more drug in skin than Sandimmun Neoral ○R did. Results showed that flexible liposomes can transport cyclosporin A through mouse skin efficiently and drug tended to be accumulated in tissues rich of fat, like kidney and skin.