先天性淋巴细胞
免疫学
先天免疫系统
趋化因子
生物
过敏性炎症
记忆B细胞
滤泡树突状细胞
树突状细胞
细胞生物学
T细胞
免疫系统
炎症
B细胞
抗原提呈细胞
抗体
作者
Timotheus Y.F. Halim,You Yi Hwang,Seth Thomas Scanlon,Habib Zaghouani,Natalio Garbi,Padraic G. Fallon,Andrew N. J. McKenzie
摘要
Rapid activation of memory CD4(+) T helper 2 (TH2) cells during allergic inflammation requires their recruitment into the affected tissue. Here we demonstrate that group 2 innate lymphoid (ILC2) cells have a crucial role in memory TH2 cell responses, with targeted depletion of ILC2 cells profoundly impairing TH2 cell localization to the lungs and skin of sensitized mice after allergen re-challenge. ILC2-derived interleukin 13 (IL-13) is critical for eliciting production of the TH2 cell-attracting chemokine CCL17 by IRF4(+)CD11b(+)CD103(-) dendritic cells (DCs). Consequently, the sentinel function of DCs is contingent on ILC2 cells for the generation of an efficient memory TH2 cell response. These results elucidate a key innate mechanism in the regulation of the immune memory response to allergens.
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