A Strategy to Induce Calcium Ion Storm in Cancer Stem Cells for Efficient Cancer Therapy

experimental results show that HMCPN-CE3@HA4 can significantly inhibit the stemness of MOC1 side population (SP) stem cells and produce significant toxicity, resulting in nearly 80% cell death. After intravenous administration, HMCPN-CE3@HA4 exhibits superior antitumor efficacy and excellent biosafety.