自愈水凝胶
体内
胚胎干细胞
肽
干细胞
缺血
化学
心肌梗塞
药理学
生物医学工程
生物物理学
医学
细胞生物学
生物化学
心脏病学
生物
高分子化学
生物技术
基因
作者
Abhishek Roy,Hao Líu,Jamie Francisco,Jian Guan,Satvik Mareedu,Peiyong Zhai,Joseph Dodd‐o,Corey Heffernan,Dominic P. Del Re,Eun Jung Lee,Vivek Kumar
标识
DOI:10.1021/acs.biomac.3c01345
摘要
Myocardial infarction (MI) is a major cause of morbidity and mortality worldwide, especially in aging and metabolically unhealthy populations. A major target of regenerative tissue engineering is the restoration of viable cardiomyocytes to preserve cardiac function and circumvent the progression to heart failure post-MI. Amelioration of ischemia is a crucial component of such restorative strategies. Angiogenic β-sheet peptides can self-assemble into thixotropic nanofibrous hydrogels. These syringe aspiratable cytocompatible gels were loaded with stem cells and showed excellent cytocompatibility and minimal impact on the storage and loss moduli of hydrogels. Gels with and without cells were delivered into the myocardium of a mouse MI model (LAD ligation). Cardiac function and tissue remodeling were evaluated up to 4 weeks in vivo. Injectable peptide hydrogels synergized with loaded murine embryonic stem cells to demonstrate enhanced survival after intracardiac delivery during the acute phase post-MI, especially at 7 days. This approach shows promise for post-MI treatment and potentially functional cardiac tissue regeneration and warrants large-scale animal testing prior to clinical translation.
科研通智能强力驱动
Strongly Powered by AbleSci AI