淋巴系统
水肿
医学
淋巴水肿
病理
重症监护医学
内科学
癌症
乳腺癌
出处
期刊:Clinical Science
[Portland Press]
日期:2023-09-01
卷期号:137 (18): 1451-1476
摘要
Abstract Resolution of edema remains a significant clinical challenge. Conditions such as traumatic shock, sepsis, or diabetes often involve microvascular hyperpermeability, which leads to tissue and organ dysfunction. Lymphatic insufficiency due to genetic causes, surgical removal of lymph nodes, or infections, leads to varying degrees of tissue swelling that impair mobility and immune defenses. Treatment options are limited to management of edema as there are no specific therapeutics that have demonstrated significant success for ameliorating microvascular leakage or impaired lymphatic function. This review examines current knowledge about the physiological, cellular, and molecular mechanisms that control microvascular permeability and lymphatic clearance, the respective processes for interstitial fluid formation and removal. Clinical conditions featuring edema, along with potential future directions are discussed.
科研通智能强力驱动
Strongly Powered by AbleSci AI