消炎药
一氧化氮
化学
EC50型
IC50型
体外
人类免疫缺陷病毒(HIV)
传统医学
化学成分
药理学
立体化学
生物化学
生物
色谱法
有机化学
医学
免疫学
作者
Yong Zhang,Jiaming Guo,Mingming Zhang,Qianqian Wang,Chengyuan Liang,Yi-Meng Zhao,Yuling Deng,Yanping Liu,Yan-Hui Fu
出处
期刊:Molecules
[MDPI AG]
日期:2023-08-14
卷期号:28 (16): 6050-6050
标识
DOI:10.3390/molecules28166050
摘要
Four new xanthones, cratocochinones A–D (1–4), together with eight known analogues (5–12), were isolated from the stems and leaves of Cratoxylum cochinchinense. The chemical structures of cratocochinones A–D (1–4) were elucidated by comprehensive spectroscopic analyses and the known compounds were identified by comparisons with the spectral data reported in the literature. All isolated compounds 1–12 were evaluated for their anti-inflammatory activities and anti-HIV-1 activities. Compounds 1–12 showed remarkable inhibitory activities on nitric oxide (NO) production induced by lipopolysaccharide in mouse macrophage RAW 264.7 cells in vitro, with IC50 values in the range of 0.86 ± 0.05 to 18.36 ± 0.21 µM. Meanwhile, compounds 1–12 exhibited significant anti-HIV-1 activities with EC50 which ranged from 0.22 to 11.23 µM. These findings indicate that the discoveries of these xanthones, isolated from the stems and leaves of C. cochinchinense, showing significant anti-inflammatory and anti-HIV-1 effects could be of great importance to the research and development of new natural anti-inflammatory and anti-HIV agents.
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