旁侵犯
医学
内科学
肿瘤科
基底细胞
队列
头颈部癌
总体生存率
头颈部鳞状细胞癌
癌症
头颈部
外科
作者
Shaheen Hasmat,Gillian Z. Heller,Lachlan Cook,Ruta Gupta,Jonathan R. Clark,Eng H. Ooi,Tsu‐Hui Low
出处
期刊:Head & neck
[Wiley]
日期:2023-08-10
卷期号:45 (10): 2605-2612
被引量:4
摘要
Abstract Background Perineural invasion (PNI) in oral squamous cell carcinoma (OSCC) does not contribute to the current American Joint Committee on Cancer 8th edition (AJCC8) staging manual. This study seeks to validate the effect of multifocal PNI in a large cohort of patients. Methods Patients undergoing primary surgical treatment of OSCC with curative intent between 1995 and 2022 was retrieved from two Australian head and neck databases. PNI was categorized as a single focus or multiple foci. Study end points included disease‐specific survival (DSS) and overall survival (OS). Results Complete data for survival analysis was available in 993 patients. Multifocal PNI was associated with a 61% increased risk of death due to OSCC (HR 1.61, 95% CI 1.11–2.33, p = 0.014) and a 32% increased risk of death from any cause (HR 1.32, 95% CI 1.01–1.73, p = 0.045). Conclusions Multifocal PNI is a significant predictor of survival in OSCC.
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