A Conjugated molecule based on tetra-fused thienoisoindigo ribbon for NIR-II photothermal cancer therapy

Water-soluble nanoparticles (NPs) based on the well-defined 4ThIID molecules, namely 4ThIID NPs, were prepared. Benefiting from the strong NIR-II absorption and high photothermal conversion properties of 4ThIID, the ε1064 × PTCE1064 value of 4ThIID NPs reaches 9.18 × 104, which is the highest value among the reported NIR-II photothermal small molecules. In vivo experiments show that 4ThIID NPs can effectively inhibit the growth of tumors in mouse models under the irradiation of a 1064 nm laser.