自愈水凝胶
化学
药物输送
聚合物
水杨酸钠
透明质酸
魔角纺纱
化学工程
高分子化学
核磁共振波谱
立体化学
有机化学
遗传学
生物
工程类
作者
Valeria Vanoli,Sara Delleani,Mosè Casalegno,Fabio Pizzetti,Pooyan Makvandi,Håvard Jostein Haugen,Andrea Mele,Filippo Rossi,Franca Castiglione
标识
DOI:10.1016/j.carbpol.2022.120309
摘要
Hydrogels based on hyaluronic acid (HA) and agarose-carbomer (AC) raised an increasing interest as drug delivery systems. The complex architecture of the polymer network, such as mesh size, HA molecular weight and drug-polymer non covalent interactions across the 3D polymer matrix strongly influence the release capability/profile of these materials. In this study, AC-HA hydrogels with different mesh sizes have been prepared and characterised. High Resolution Magic Angle Spinning (HR-MAS) NMR spectroscopy has been used to investigate the motion of two drugs, such as ethosuximide (neutral molecule) and sodium salicylate (net negative charge) within the AC and AC-HA hydrogel networks. Analysis of the experimental data provides evidence of superdiffusive motion for all formulations containing sodium salicylate, while ethosuximide molecules undergo unrestricted diffusion within the gel matrix. We further speculate that the superdiffusive motion, observed at the nanoscale, can be responsible for the faster release of sodium salicylate from all hydrogel formulations.
科研通智能强力驱动
Strongly Powered by AbleSci AI